It was shown that DHX9 supports NF-κB-mediated transcriptional activity by increasing p65 phosphorylation and nuclear translocation, another, DHX9 interacts with p65 and RNA polymerase II to bolster the expression of NF-κB's downstream targets, such as Snail and Survivin, thus intensifying the cancerous characteristics of colorectal cancer 48. This evidence concerns the gene BIRC5 and colorectal cancer.