Growth differentiation factor GDF15 (also known as macrophage inhibitory cytokine 1 (MIC‐1), a member of transforming growth factor (TGF‐β) superfamily, was identified as a biomarker of aging, frailty, and metabolic disorders (Berezin, 2016; Fujita et al., 2016). This evidence concerns the gene GDF15 and metabolic disease.