The significantly lower rate of PD‐L1‐positive tumor cells and macrophages, as well as of intratumoral CD8‐positive and CD4‐positive lymphocytes, M2 macrophages, and dendritic cells in MTAP‐deficient urothelial carcinomas is consistent with more efficient immune evasion in these tumors. This evidence concerns the gene CD4 and urothelial carcinoma.