Of interest, RPL29 was identified as an oncoprotein in various cancers, such as pancreatic cancer, lung cancer, and colon cancer.[43, 44, 45] Consistent with the previous reports, our results demonstrated that RPL29 plays an important role in sustaining the survival and self‐renewal characteristics of primary human CML LSCs. This evidence concerns the gene RPL29 and malignant colon neoplasm.