CD34 and chronic myelogenous leukemia, BCR-ABL1 positive: In addition, we found that restoration of PRMT1WT but not PRMT1E153Q rescued the impaired CML progenitor activity mediated by PRMT1 knockdown (Figure 1K,L), suggesting that PRMT1 enhances the serially plating capacity of CML CD34+ cells depending on its methyltransferase activity.