Consistently, the mRNA expression of PRMT1 was higher in leukemia stem/progenitor cells (LSPCs) sorted from individuals with CML (CML CD34+) than in hematopoietic stem/progenitor cells (HSPCs) sorted from healthy donors (normal CD34+) (Figure 1B). This evidence concerns the gene PRMT1 and chronic myelogenous leukemia, BCR-ABL1 positive.