PRMT1 knockdown obviously reduced the expression of RPL29 and H4R3me2a in CML CD34+ cells (Figure 4F,G), suggesting that PRMT1 may induce RPL29 expression by catalyzing the methylation of H4R3 at the gene promoter of RPL29. The gene discussed is PRMT1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.