Silencing Rpl29 significantly prolonged the survival (median survival: Scr vs shRpl29 #1 vs shRpl29 #2 was 16 days vs not reached after monitoring for 50 days; Figure S10C, Supporting Information), obiviously alleviated the splenomegaly and the spleen weight of CML mice (Figure S10D,E, Supporting Information). The gene discussed is RPL29; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.