PRMT1 is the predominant type I arginine methyltransferase and is responsible for 85% of arginine methylation in mammalian cells.[20] Among the PRMTs family, PRMT1 predominantly catalyzes asymmetric dimethylation of histone H4R3 (H4R3me2a) which correlates with transcriptional activation.[21] Dysregulation of PRMT1 has been observed in several cancer types. This evidence concerns the gene PRMT1 and cancer.