Interestingly, siLYL1 induces BHLHE40 expression in both PCa cell lines (Fig. 2C-E) and suggests a negative feedback loop between LYL1 and BHLHE40 by which BHLHE40 enhances LYL1, which in turn suppresses BHLHE40 expression. The gene discussed is BHLHE40; the disease is posterior cortical atrophy.