To investigate the role of LYL1 in growth and induction of cellular senescence in PCa cells, first the levels of p27kip1 were analyzed by SAL treatment and by the KD of BHLHE40. The data suggest an upregulation of the cell cycle inhibitor and senescence inducer p27kip1 [45] by SAL and a blunted induction via the KD of BHLHE40 in both cell lines (Fig. 1C). This evidence concerns the gene CDKN1B and posterior cortical atrophy.