The influenza A virus (Flu) is also mainly recognized by RIG-I (Kato et al, 2006; Lopez et al, 2004), and pitavastatin treatment increased the levels of IFN-β proteins produced by HeLa cells in response to infection with Flu or SeV (Figs. 1F,G and EV1D), although Flu infection alone hardly produced the IFN-β protein in HeLa cells under our experimental condition. Here, RIGI is linked to infection.