CA supplementation also induced a 1.45‐fold increase in plasminogen activator inhibitor‐1 (PAI‐1) which regulates the fibrinolytic system and whose expression is induced by pro‐inflammatory cytokines (Morrow et al., 2021), and a 1.65‐fold increase in retinol binding protein 4 (RBP4) that is known to be increased in mouse models of obesity and insulin resistance (Tamori et al., 2006). The gene discussed is SERPINE1; the disease is Insulin resistance.