As predicted by the bioinformatics website starBase 3.0, miR-15a-5p targets EZH1 which has a binding site for miR-15a-5p (Fig. 5A), and EZH1 in ALI was determined by RT-qPCR and Western Blot, and it was found in the plasma of patients with sepsis and in MLE-12 cells with a high expression of EZH1 (Fig. 5B and C). This evidence concerns the gene EZH1 and acute respiratory distress syndrome.