The MICOS literature also report evidence of mitochondrial fusion and fission imbalance in Neuro-2a cells expressing ApoE4.[44] Previous analysis of AD brains indicated diminished protein levels connected to mitochondrial fusion/fission[50], which our data supports as a degradation driven loss of fusion proteins (See Figs DA and DB in S1 File). The gene discussed is APOE; the disease is Alzheimer disease.