LGR5 and colitis: Orthogonal support for stem cell stress was provided by analyzing N1RA/RA; N2RA/RA; Lgr5-EGFP-IRES-creERT2 mice, which lost weight rapidly from day 4 relative to N1+/+; N2+/+; Lgr5-EGFP-IRES-creERT2 when exposed to 2% DSS to induce colitis (S1B Fig).