In ovarian cancer, the overexpression of the small GTPase Rab25 promotes the internalisation of fibronectin-occupied α5β1 integrin to sustain invasive migration [41]; therefore, we measured ECM internalisation in the highly invasive ovarian carcinoma cell line A2780, overexpressing Rab25 (A2780-Rab25). This evidence concerns the gene FN1 and ovarian carcinoma.