Of note, COE time course and dose-dependent induction of phospho-(S473)-AKT levels along with significant reduction in phospho (T180 + Y182) P38 levels was previously reported in another study in which the protective effect of CBD in an experimental multiple sclerosis model was mediated by increase in Phospho-AKT and a reduction in P38 MAPK activity [36]. The gene discussed is AKT1; the disease is multiple sclerosis.