In this study, we determined that OHCT might regulate multiple targets including ITGA1, ITGA4, ITGA5, ITGB5, ENG, MMP14, SERPINH1, THY1, TAGLN, IGF1, CDK1 and CD44, etc., focal adhesion and the PI3K-Akt pathway and other pathways to alleviate RA. Here, ENG is linked to rheumatoid arthritis.