ITGB2 can bind with ITGAL, ITGAM, ITGAX, or ITGAD to form different phenotypes of β2 integrins based on various immune cell types.[68] The ITGAL/ITGB2 heterodimer, denoted as LFA‐1, is expressed in all lymphocytes and leukocytes and is particularly important for T cell function and inflammation.[36] In endometriosis, we first observed the overexpression of ITGB2 in patients, as evident by the results from both transcriptomic datasets and IHC staining (Figure 5). Here, ITGAL is linked to endometriosis.