HCK and endometriosis: GBP2 is a guanylate‐binding protein implicated in regulating immune and inflammatory processes,[31, 32] while HCK is a Src family kinase involved in cell proliferation and survival signaling.[33, 34] To validate these targets, we conducted targeted knockdown experiments using small interference RNA (siRNA) and demonstrated that inhibition of either GBP2 or HCK suppressed proliferation and stimulated apoptosis of ectopic endometrial cells both in vitro and in vivo, suggesting their potential regulatory roles in immune response and growth of ectopic endometrial tissue in endometriosis.