TLR9 and Sepsis: However, spleen and liver IL-1β levels were concordant with plasma levels in WT but not Erytlr9–/– mice, and tissue IFN-γ levels were discordant with plasma levels in both WT and erythroid Tlr9–deficient mice (Supplemental Table 2), suggesting that plasma IFN-γ may not be a surrogate for tissue-level pathology during sepsis.