Patient 2 exhibited symptoms of acute heart failure and arrhythmia associated with clinical manifestations of VEXAS syndrome (eg, skin lesions, chondritis), which were managed with heart failure treatment and antiarrhythmic agents, alongside interleukin 6 inhibitor tocilizumab and corticosteroids; other VEXAS symptoms were stabilized. This evidence concerns the gene IL6 and Arrhythmia.