UBA1 and VEXAS syndrome: VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome is associated with somatic variations in the UBA1 gene within hematopoietic progenitor cells.1 It is characterized by fever and systemic manifestations, including cutaneous, lung, ocular, and musculoskeletal issues,2 with thrombosis and myocardial infarctions in approximately 6% of patients.3 Nonischemic cardiac manifestations, such as pericarditis or myocarditis, have ocurred in 4% to 33% of cases, although no studies have focused on heart involvement in VEXAS syndrome.1,2,3