FANCB and neoplasm: However, the effective half-life (t1/2e) which incorporates physical decay and biological eliminationis the most important for designing biodistribution studies to estimatedosimetry.23 In our study, we employedfour time points which were selected based on the relative eliminationrates of [225Ac]Ac-DOTA-trastuzumab IgG, F(ab')2 or Fab and we fitted the elimination curves for all tissuesexceptthe tumor and spleen to a one-phase exponential decay curve to accuratelycapture the elimination phase of activity from these tissues.