COG2 and amyotrophic lateral sclerosis: We showed further that the predictive value of these biomarkers declined over time in general, and that some biomarkers were predictive of survival only during the first year (e.g., total cholesterol, LDL-C, and apolipoprotein B), whereas others during the entire 3 years (e.g., albumin, MCV, CO2, and NfL) after ALS diagnosis.