Yuan et al. (2016) showed that EGR1 expression was significantly increased in aged mouse ovaries compared to the ovaries of young mice and increased follicular atresia in aged mice (Yuan et al. 2016). The increased expression of EGR1 by LY294002 suggests that AKT signaling could also play a role in preventing ovarian fibrosis, ovarian hyperstimulation syndrome and follicular atresia via controlling the expression of EGR1. This evidence concerns the gene AKT1 and ovarian hyperstimulation syndrome.