Mechanistically, we uncovered that PRL2 can post-translationally down-regulate PTEN, a tumor suppressor frequently inactivated in human cancers [17,18], by dephosphorylating PTEN at Tyr336, thereby promoting NEDD4-mediated PTEN ubiquitination and proteasomal degradation [19]. The gene discussed is PTP4A2; the disease is neoplasm.