Genes harbouring predisposition variants fell into one of three categories: 1) established Wilms tumour predisposition changes, including chromosome 11p loss of heterozygosity (LOH)/imprinting (LOI) (n=54 children); 2) cancer predisposition genes that are not usually associated with Wilms tumour (n=13; including one child with two pathogenic germline mutations, in TP53 (p.R267W) and in NF1 (p.W784R); 3) novel putative Wilms tumour predisposition genes (n=4 children) (Figure 1A). This evidence concerns the gene NF1 and Wilms tumor.