Our previous research revealed that, after the infection of the target host cell (equine monocyte-derived macrophages [eMDMs]) with EIAVFDDV13, IFN-β expression was upregulated by about fourfold at 12 h and 20-fold at 36 h but reduced to the same level as the control group at 48 h (20). Here, IFNB1 is linked to infection.