As shown in Table 3, variables affecting the occurrence of severe RIOM include PNI trajectory categories, occupational status, years of betel nut chewing, cancer type, disease duration (years), degree of differentiation, number of comorbidities, diabetes, surgery, nasogastric intubation, radiotherapy dose, platelets, monocytes, total protein, albumin, and globulin. The gene discussed is ALB; the disease is diabetes mellitus.