ACTA1 and renal fibrosis: In addition to the traditional origins of myofibroblasts, injured TECs are also important precursors of myofibroblasts in renal fibrosis.[34, 53] However, recent genetic lineage analyses demonstrated that epithelial cells cannot be transformed into myofibroblasts through EMT.[109] Rather, pericytes and perivascular fibroblasts may be the origin of myofibroblasts.[58, 60] For example, Ivica Grgic and colleagues labeled all renal epithelial cells via two transgenic mouse models and were unable to identify genetically labeled cells in the interstitial space within the α‐SMA+ myofibroblasts.