STAT3 and renal fibrosis: Pathogenic IL‐11 signaling also plays an important role in alcoholic liver disease.[345] TGF‐β‐activated HSCs lead to the upregulation of IL‐11, resulting in a profibrotic response through ERK signaling.[346] In renal fibrosis, aberrant expression of IL‐11 is closely associated with the EMT of TECs via STAT3 and ERK signaling.[347] In this study, knockout of IL‐11 significantly alleviated renal fibrosis in a UUO mouse model.