GSDMD and Hepatic fibrosis: Furthermore, deletion of receptor tyrosine kinase ephrin type B receptor 2 (RphB2), a downstream effector of the NOTCH signaling pathway in hepatocytes, can alleviate hepatic inflammation and fibrosis.[164] In addition, specific deletion of the NOD‐like receptor 3 (NLRP3) inflammasome and downstream Gasdermin D attenuates hepatic fibrosis.[165] Intriguingly, the interactions between cell components also contribute to hepatic fibrosis.