CB2 knockdown suppresses TGF‐β signaling in TECs, inhibiting renal fibrosis.[506] A previous study revealed that CB2Rs promote renal fibrosis by activating the WNT/β‐catenin signaling pathway.[435] Hence, the specific mechanism underlying the relationship between CB2Rs and fibrosis needs further research. This evidence concerns the gene CNR2 and renal fibrosis.