FN1 and Hepatic fibrosis: In addition, some parenchymal cells activated by injury also engage in fibrogenic responses, such as the activation of hepatic stellate cells (HSCs) in hepatic fibrosis.[8] Although this fibrogenic response may be beneficial and critical in the early stage of tissue repair, prolonged accumulation of ECM (e.g., collagen and fibronectin) destroys the structure of the parenchymal capsule and leads to cellular dysfunction and organ failure.[9]