Since activation of the cGAS‐STING pathway is essential for both senescence and the innate immune response, researchers have designed a cGAS‐STING stimulator that combines prosenescence with enhanced immune clearance through targeted delivery of manganese (a cGAS‐STING stimulator) via albumin‐mediated transcytosis, specifically aimed at inducing senescence and eliminating activated HSCs in hepatic fibrosis. The gene discussed is CGAS; the disease is Hepatic fibrosis.