Lyn reportedly forms protein complexes with EPHA2, regulating epithelial–mesenchymal plasticity and metastasis in breast cancer.[24] Additionally, Lyn interacts with CD24 to activate ERK1/2 and promote CRC metastasis.[25] Our study revealed the interaction between Lyn and RUVBL1 in CRC. The gene discussed is CD24; the disease is breast carcinoma.