CHD6 recruits TCF4 to control the TMEM65 protein, which increases mitochondrial function and ATP production, leading to liver metastasis in CRC.[61] After we knocked down Lyn, the differentially expressed genes identified via ATAC‐seq were enriched mainly in metabolic pathways, and the differentially expressed genes identified via HiCuT of Lyn/RUVBL1 were enriched mainly in fatty acid synthesis. The gene discussed is TCF4; the disease is colorectal carcinoma.