Multiple studies have shown that MMP9 and VEGF promote liver metastasis in CRC.[34, 35, 36] Our previous research demonstrated that DC‐SIGN induces the nuclear translocation of β‐catenin by recruiting Lyn to form protein complexes, thereby increasing the expression of MMP9 and VEGF and promoting the migration and invasion of colon cancer cells.[37] Compared with the control, Lyn, RUVBL1, or both considerably inhibited the nuclear translocation of β‐catenin (Figure 3F,G). The gene discussed is VEGFA; the disease is colonic neoplasm.