Lyn reportedly forms protein complexes with EPHA2, regulating epithelial–mesenchymal plasticity and metastasis in breast cancer.[24] Additionally, Lyn interacts with CD24 to activate ERK1/2 and promote CRC metastasis.[25] Our study revealed the interaction between Lyn and RUVBL1 in CRC. Here, EPHA2 is linked to breast carcinoma.