This finding aligned with Zhou et al.’s conclusion that adventitial progenitor cells were mobilized for repair primarily in response to severe injuries (such as angiotomy), while minimal injuries (such as wire injury and atherosclerosis) yielded few detectable progenitor cells.[45] Collectively, our finding supported that the VSMCs‐derived FSP1+ fibroblast‐like cells played a more significant role in plaque stabilization and repair process following plaque rupture. Here, S100A4 is linked to atherosclerosis.