In a positive feedback mechanism, activated monocytes, in turn, induce platelet activation leading to TGFβ1 release and monocyte nuclear localization of nuclear factor B. Furthermore, the complete silencing of platelet TGFβ1 (breaking the positive feedback loop) significantly promoted the resolution of inflammation and vasculopathy in the LCWE‐induced murine model. Here, TGFB1 is linked to vascular disorder.