The predicted LIC_10507, LIC_10508, and LIC_10509 are located at the surface of pathogenic leptospires, expressed during infection of guinea pigs experimentally infected; these proteins induced the upregulation of ICAM‐1 and E‐selectin adhesion molecules in human umbilical vein endothelial cells (HUVECS) [72]. This evidence concerns the gene ICAM1 and infection.