However, phosphorylation levels of PKA‐RII, PKA‐C, and CREB were significantly different among groups in mouse prefrontal cortex and in vitro primary neuronal models, and the expression of PKA‐RIIS99, PKA‐CT197, and CREBS133 were significantly increased in TBI+PTSD models (Figure 5F; Figure S6F, Supporting Information). The gene discussed is CREB1; the disease is post-traumatic stress disorder.