In addition, in an in vitro model, 43–242aa monoclonal antibodies were added to the cell culture medium simultaneously with Hcort, and it was found that the expression of inflammation‐related markers IL‐1β, TNF‐α, IL‐10 and depression‐related markers ERCCL2, SLC6A4, and GAD1 were alleviated in the 43–242aa monoclonal antibodies treatment group compared with either the Hcort group or the TBI combined with Hcort treatment group (Figure S9A, Supporting Information). Here, IL1B is linked to major depressive disorder.