In this study, we demonstrated that TRAF2 induced CD47 ubiquitination, which in turn inhibited CD47 autophagic degradation, and a high level of CD47 on cancer cells blocked macrophage phagocytosis leading to the promotion of NSCLC tumor immune escape, which revealed a novel mechanism of tumor immune escape. This evidence concerns the gene TRAF2 and non-small cell lung carcinoma.