Protein modification regulates its stability,[33] and ubiquitin–proteasome system (UPS) and autophagy pathways both able to induce targeted proteins degradation.[35] Other report shows that lysosome inhibitor treatment lead to accumulation of CD47 protein levels in A549 lung cancer cells,[36] suggesting that CD47 undergoes autophagic degradation on physiological conditions. The gene discussed is CD47; the disease is lung carcinoma.