CD47 and neoplasm: Whereas SIRPα‐CD47 checkpoint blockade promotes phagocytosis by phagocytes such as macrophages and dendritic cells (DCs) leading to tumor regression by activation of innate immune response.[39, 40, 41] Consistently, induction of autophagy significantly induced CD47 autophagic degradation and promoted macrophage phagocytosis, which in turn inhibited tumor immune escape.