These observations are consistent with a recently published study that PA accumulation markedly increased plaque burden and triggered cardiovascular risks in patients with Type 2 Diabetes Mellitus.[26] Interestingly, the detrimental role of PA in the cardiovascular system was only observed in the ApoE−/− mice, but not in the normal control C57BL/6 mice (Figure S9, Supporting Information). This evidence concerns the gene APOE and diabetes mellitus.