SERPINE1 and type 2 diabetes mellitus: Previous studies have established a positive correlation between Serpine1 and coronary artery calcification in patients with type 1 diabetes.[65] Additionally, we found that Serpine1 was highly expressed in the peripheral blood of patients with T2D VC, and the constructed multiple logistic regression model we constructed showed a strong positive correlation with T2D VC (Figure 7; Table 3).