ELISA indicated that Serpine1 was significantly elevated in the macrophage culture supernatant (3.85‐fold; 2.44 pg ml−1 vs 9.42 pg ml−1; Figure 7E) after BF EV stimulation and in T2D VC serum (1.68‐fold; 102.8 pg ml−1 vs 172.9 pg ml−1; Figure 7F). The gene discussed is SERPINE1; the disease is type 2 diabetes mellitus.