AHNAK and gout: Colchicine suppressed M1 macrophage polarization and induced M2macrophage polarization by binding to AHNAK protein, thereby alleviating gout.Colchicine incorporated into R4F-NM@F127 nanocarriers can serve as a targetedtherapeutic drug to regulate macrophage polarization, alleviate gout, and reducetoxicity to normal tissues.