Studies have shown that TEAS, by adjusting the SIRT1/FOXO3a and SIRT1/BRCC3/NLRP3 signaling pathways following ischemic stroke, inhibits cell apoptosis, oxidative stress, and inflammation of the nerve to reduce brain damage (Tan et al., 2024) and accelerates the recovery of neurons and some functional metabolism (Nelles et al., 2001). Here, FOXO3 is linked to ischemic stroke.