UBR5 and malignant colon neoplasm: Two of them, PATL1 and PRRC2B were discussed earlier; SENP7 is a marker of poor prognosis in colon cancer (55); SPAG9 is expressed in a variety of malignancies and regulated by QKI in lung cancer (56); UBR5 promotes postsurgical breast cancer lung metastases (57), and NSD1 exerts tumor suppressive functions (58).