Similarly, autophagy activation in gastric cancer significantly enhances the interaction between p62 and Keap1 while simultaneously inhibiting the binding of Nrf2 to Keap1, which reduces the ubiquitination and degradation of Nrf2; this results in a sustained activation of the Nrf2 signaling pathway and inhibition of malignant progression 122. Here, KEAP1 is linked to gastric cancer.