Furthermore, we demonstrated that NR4A3 induces cell cycle arrest from G0/G1 to S phase and may promote DNA damage by decreasing levels of CDK4/CDK6/CyclinD1/PCNA and upregulating expression levels of p21/p53/γH2AX, thereby inhibiting HCC proliferation. The gene discussed is CDKN1A; the disease is hepatocellular carcinoma.