CDKN2AIP and hepatocellular carcinoma: Moreover, western blot analyses were performed on 42 paired HCC and matched adjacent noncancerous liver tissues, and the results showed that CDKN2AIP was downregulated in HCC tissues compared with that in the paired adjacent liver tissues, and the levels of NR4A3 were lower in HCC tissues (Fig. 7G and Fig. S7A).