Previously suggested roles for NR4A3 include acting as a tumor suppressor gene within human cancers such as hematologic neoplasms including acute myeloid leukemia 32, lymphoma or gastric cancer 33-35; however, it has also been reported to act an oncogene within AciCC or neuroblastoma 36-38 indicating its dual functionality across different cancers. This evidence concerns the gene ENSG00000280371 and gastric cancer.