Consistently, RIP data showed significantly elevated binding of v2 to both total STAT3 and p-STAT3 (Tyr705), whereas stronger binding to p-STAT3 than total STAT3 was observed in v1-overexpresssing cells (Figure 4B), implicating variant-specific modulation of STAT3 signaling activation by LOC344887 in HCC. Here, TRGV9 is linked to hepatocellular carcinoma.