Together, present findings implicated a novel signaling axis orchestrated by LOC344887, with an emphasis on LOC344887-v2, which elicited more potent activation of STAT3 signaling, prevention of SHP-1 dephosphorylation and upregulation of HMGA2 in driving HCC migration and metastasis (Figure 7). This evidence concerns the gene HMGA2 and hepatocellular carcinoma.