STAT3 and hepatocellular carcinoma: Notably, the elevated cell mobility of HCC cooperatively modulated by LOC344887 and SHP1 was attributed to significantly activated STAT3 phosphorylation by SHP-1 knockdown (Figure 5D), as the reduced p-STAT3 by LOC344887 knockdown was greatly ameliorated under SHP-1 knockdown (Figure 5D, lane 2 vs. lane 4).