The CCK-8 assay, EDU assay, and Annexin V/7AAD staining assay revealed that silencing IKBKE increased sunitinib sensitivity in renal cancer cells (Figure 6A-B, 6E-F), while overexpression of IKBKE decreased the sensitivity of renal cancer cells to sunitinib (Figure 6C-D, 6G-H). Here, ANXA5 is linked to renal carcinoma.