The efficiency of BRD7 and METTL3 expression was confirmed by western blotting (Figure 6A), and the CCK-8 and clonogenic survival assays showed that restoring METTL3 expression at least partially reversed the promotive effect of BRD7 overexpression on the cytotoxic effect of irradiation on NPC cells (Figure 6B-D). The gene discussed is BRD7; the disease is nasopharyngeal carcinoma.