H2AX and neoplasm: In line with the results observed in vitro, the tumor volume and weight measurements showed that ectopic expression of BRD7 promoted the tumoricidal effect of radiotherapy, i.e., exerted a radiosensitizing effect, while ectopic expression of METTL3 hindered the radiosensitizing effect, and restoring METTL3 expression in BRD7-overexpressing cells antagonized the radiosensitizing effect of BRD7 on NPC cells (Figure 7A-C), and these findings were further confirmed by results of γ-H2AX staining (Figure 7D).