METTL3 and neoplasm: To further validate the role of the BRD7/METTL3 axis in the radiosensitivity of NPC in vivo, the aforementioned NPC cells were subcutaneously injected into the right flanks of 5-week-old female nude mice for xenograft tumor formation, with a control group, a BRD7 overexpression group, a METTL3 overexpression group, and a BRD7 overexpression followed by METTL3 rescue group established.