CREB1 and pancreatic neoplasm: Furthermore, ZIP4 not only promotes the progression of pancreatic cancer through the CREB-activated syndecan 1 (SDC1) and dynamin 2 (DNM2) pathway but also promotes the glycogen synthase kinase 3β(GSK3β)/necrosis factor superfamily member 10 (TRAIL) pathway to drive muscle consumption, thereby aggravating cachexia 102.