P2RX7 and cardiac hypertrophy: On the one hand, Yang et al. (2022) demonstrated that FAM134B-mediated ER-phagy triggered by apelin-13 induces myocardial hypertrophy through activation of the pannexin-1/eATP/P2X7 axis, whereas inhibition of FAM134B-mediated ER-phagy alleviates apelin-13-induced cardiac hypertrophy.