A reduction in the IFN-inducible expression of UBP43 leads to a notable delay in the negative feedback regulation of type-I interferon signaling in Burkitt lymphoma (BL) cell lines (including Akata A.2 and A.15), regardless of their Epstein–Barr virus (EBV) status (Ruf et al., 2009). The gene discussed is USP18; the disease is Burkitt lymphoma.