Inhibition of this USP using siRNA downregulates the expression of Mcl-1 and upregulates the expression of caspase-3, Bak, and cytochrome C; therefore, knockdown of USP9X induces cell apoptosis and decreases cell proliferation in DLBCL (Peng et al., 2020). The gene discussed is USP9X; the disease is diffuse large B-cell lymphoma.