For instance, mutant TP53 can promote tumor progression by altering exosome content, leading to the reprogramming of macrophages into the M2 phenotype, which creates a TME more conducive to liver cancer progression (Huang, 2021; Hernández Borrero and El-Deiry, 2021; Hu et al., 2021). The gene discussed is TP53; the disease is neoplasm.