Key immune cells, such as Kupffer cells and cytotoxic T lymphocytes, play crucial roles in the development of HCC, providing ample opportunities for research into HCC immunotherapy (Jiang et al., 2023).Current studies suggest that RRx-001 mechanisms of anticancer activity involve downregulating CD47 to enhance chemotherapeutic immunity. The gene discussed is CD47; the disease is hepatocellular carcinoma.