Although a triple combination (Cap, IR, and 17-AAG) was tested, it was less effective in downregulating MMP-9 and VEGF and did not significantly inhibit cell migration, suggesting that the double combinations are more effective for anti-metastatic and anti-angiogenic effects in CRC (Zeynali-Moghaddam et al., 2019). The gene discussed is VEGFA; the disease is colorectal carcinoma.