PD-1 cis-targeted IL-2/IL-15R agonists, such as PD-1/IL-2v, PD-1-laIL-2, αPD1-IL15m, and αPD1-IL15-R, can selectively deliver the attenuated IL-2 or IL-15 to PD-1+CD8+ TILs, bypass NK cells, and exert significantly antitumor activity in multiple tumor models30,35,43,.44 The gene discussed is IL15; the disease is neoplasm.