ABCC2 and metabolic dysfunction-associated steatohepatitis: These data, taken in conjunction with the tissue data that showed an increase in hepatic SFB-G concentrations in Mrp2 knockout animals but a significant decrease in the knockout MCD group, indicate that the disruption of biliary efflux via Mrp2 is not the sole mediator of plasma retention of SFB-G, and that alterations to sinusoidal uptake and efflux during MCD diet-induced NASH contributed to the changes in SFB-G pharmacokinetics.