These data confirm that the hepatocellular shuttling of SFB-G is significantly impaired during NASH due to disruption of the three cooperative transport mechanisms of 1) increased Mrp3 sinusoidal efflux, 2) impaired Mrp2 biliary efflux due to mislocalization, as well as 3) decreased Oatp sinusoidal uptake, and quantifies the contribution of these mechanisms towards the overall changes to SFB-G pharmacokinetics. The gene discussed is ABCC2; the disease is metabolic dysfunction-associated steatohepatitis.