The additional alterations to Mrp2 and Mrp3 function due to the effects of diet-induced NASH further exacerbate the disruption to hepatocyte hopping, as the loss of Mrp2 function prevents biliary excretion and increased Mrp3 protein expression at the plasma membrane increases the shuttling of SFB-G back into circulation. Here, ABCC2 is linked to metabolic dysfunction-associated steatohepatitis.