In mammalian lungs, Piezo1 is mainly expressed in non-excitable cells such as endothelial cells, epithelial cells, myeloid cells, and smooth muscle cells of small arteries in the lungs, and it plays a critical role in pulmonary edema, lung cancer, lung inflammation, and pulmonary hypertension; Piezo2 is expressed in the pulmonary neuroepithelial cell body, pulmonary neuroendocrine cells, and sensory neurons being associated with respiration, such as the nodose ganglion, and dorsal root ganglion in the spinal cord. This evidence concerns the gene PIEZO2 and pulmonary arterial hypertension.