The role of the other subfamilies of TPRV in VILI still needs to be elucidated and might be promising because they are reportedly involved in ovalbumin-induced asthma models (TRPV1, TRPV2, TRPV5) (68, 69), and lung epithelial injury caused by cigarette smoke (70), LPS (71), seawater inhalation (72) and wood smoke (TRPV3) (73–75). Here, TRPV3 is linked to asthma.