CTLA4 and neoplasm: Our analysis demonstrated that ARGcluster A had better survival, lower levels of immune infiltration, lower expression levels of HLA genes, lower expression levels of TIGIT, PDCD1LG2, PDCD1, LAG3, HAVCR2, CTLA4, and CD274, and lower ESTIMATE scores, immune scores, and stromal scores than ARGcluster B. The ARGcluster B had lower tumor purity than ARGcluster A. The association between low tumor purity and poor prognosis has been well-documented in previous studies (53, 54).