(116) collected biopsy specimens from 199 breast cancer patients who underwent paclitaxel-cisplatin chemotherapy and found through rank tests and Cox proportional regression analysis that the expression of ACSL4 and the combination status of ACSL4/GPX4 can serve as independent predictive factors for pathological complete response, and ACSL4 expression is positively correlated with overall survival in breast cancer patients. Here, GPX4 is linked to breast carcinoma.