A recent study (79) demonstrated that hypoxia actually sensitizes cancer cells to ferroptosis, as clear cell carcinoma is highly sensitive to ferroptosis induced by GPX4 inhibitors, driven by the hypoxia-inducible factor 2α (HIF2α) subtype through hypoxia-induced lipid droplet-associated protein (HILPDA) via PUFA lipid remodeling. This evidence concerns the gene HILPDA and clear cell adenocarcinoma.