PEDS1 and cancer: discovered that transmembrane protein 189 (TMEM189) can inhibit autophagy in TNBC cancer cells, decrease TFR1 expression and intracellular lipid reactive oxygen species (Lipid-ROS) content, alleviating ferroptosis and promoting breast cancer growth in vivo, suggesting that TMEM189 inhibitors may have a better therapeutic effect on TNBC (93).